Loading...
Loading...
Found 741 Skills
Decompose financial variances into drivers with narrative explanations and waterfall analysis. Use when analyzing budget vs. actual, period-over-period changes, revenue or expense variances, or preparing variance commentary for leadership.
Find similar vulnerabilities and bugs across codebases using pattern-based analysis. Use when hunting bug variants, building CodeQL/Semgrep queries, analyzing security vulnerabilities, or performing systematic code audits after finding an initial issue.
Creates language variants of existing Semgrep rules. Use when porting a Semgrep rule to specified target languages. Takes an existing rule and target languages as input, produces independent rule+test directories for each language.
Comprehensive structural variant (SV) analysis skill for clinical genomics. Classifies SVs (deletions, duplications, inversions, translocations), assesses pathogenicity using ACMG-adapted criteria, evaluates gene disruption and dosage sensitivity, and provides clinical interpretation with evidence grading. Use when analyzing CNVs, large deletions/duplications, chromosomal rearrangements, or any structural variants requiring clinical interpretation.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
Adversarial code review using the opposite model. Spawns 1–3 reviewers on the opposing model (Claude spawns Codex, Codex spawns Claude) to challenge work from distinct critical lenses. Triggers: "adversarial review".
Aria Attribute Helper - Auto-activating skill for Frontend Development. Triggers on: aria attribute helper, aria attribute helper Part of the Frontend Development skill category.
Devil's Advocate stress-testing for code, architecture, PRs, and decisions. Surfaces hidden flaws through structured adversarial analysis with metacognitive depth. Use for high-stakes review, stress-testing choices, or when the user wants problems found deliberately. NOT for routine code review (use engineering:code-review). Triggers on "스트레스 테스트", "stress test", "devil's advocate", "반론", "이거 괜찮아", "문제 없을까", "깊은 리뷰", "critical review", "adversarial".
Perform a Cynical Review and produce a findings report. Use when the user requests a critical review of something
Perses variable lifecycle management: create Text and List variables at global, project, or dashboard scope. Handle variable chains with dependencies (A depends on B depends on C). Supports 14+ interpolation formats. Uses MCP tools when available, percli CLI as fallback. Use for "perses variable", "dashboard variable", "perses filter", "add variable". Do NOT use for datasource management (use perses-datasource-manage).