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Found 246 Skills
Comprehensive immune repertoire analysis for T-cell and B-cell receptor sequencing data. Analyze TCR/BCR repertoires to assess clonality, diversity, V(D)J gene usage, CDR3 characteristics, convergence, and predict epitope specificity. Integrate with single-cell data for clonotype-phenotype associations. Use for adaptive immune response profiling, cancer immunotherapy research, vaccine response assessment, autoimmune disease studies, or repertoire diversity analysis in immunology research.
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
React performance optimization patterns including memoization, code splitting, bundle size reduction, re-render elimination, and profiling. Covers React Compiler automatic optimization, manual memo/useMemo/useCallback targeting, React.lazy with Suspense, barrel file avoidance, content-visibility for large lists, startTransition for non-urgent updates, and React DevTools profiling. Use when optimizing React app performance, reducing bundle size, eliminating unnecessary re-renders, debugging slow components, code splitting, or profiling rendering bottlenecks. Use for performance audit, bundle analysis, re-render diagnosis, lazy loading, virtualization.
Swift 6.2 and SwiftUI performance optimization for iOS 26 clinic architecture codebases. Covers async/await concurrency patterns, Sendable/actor isolation, view/render performance, and animation performance while preserving modular MVVM-C boundaries across App, Feature, Domain, and Data layers. Use when profiling or optimizing Swift/SwiftUI behavior in clinic modules.
Full Sentry SDK setup for Ruby. Use when asked to add Sentry to Ruby, install sentry-ruby, setup Sentry in Rails/Sinatra/Rack, or configure error monitoring, tracing, logging, metrics, profiling, or crons for Ruby applications. Also handles migration from AppSignal or Honeybadger. Supports Rails, Sinatra, Rack, Sidekiq, and Resque.
Rspack best practices for config, CLI workflow, type checking, CSS, bundle optimization, assets and profiling. Use when writing, reviewing, or troubleshooting Rspack projects.
Full Sentry SDK setup for .NET. Use when asked to "add Sentry to .NET", "install Sentry for C#", or configure error monitoring, tracing, profiling, logging, or crons for ASP.NET Core, MAUI, WPF, WinForms, Blazor, Azure Functions, or any other .NET application.
Use this skill when diagnosing, configuring, or monitoring NICs for AF_XDP / XDP workloads. Covers driver detection, hardware queue configuration, ring buffer sizing, RSS indirection table management, interrupt coalesce tuning, offload control (GSO/GRO/TSO/LRO), VLAN offloads, Flow Director (FDIR) rules with loc pinning and ixgbe wipe bug workaround, RPS/XPS queue CPU mapping, sysctl network tuning, CPU core pinning and NUMA awareness, hardware queue and drop monitoring, softirq and rx_missed_errors analysis, BPF program inspection with bpftool (prog dump xlated, net show), kernel tracing via ftrace and dmesg, perf profiling and flamegraphs, IRQ-to-queue-to-core mapping, bonding interface diagnostics, socket inspection, and a quick diagnostic checklist.
Full Sentry SDK setup for Node.js, Bun, and Deno. Use when asked to "add Sentry to Node.js", "add Sentry to Bun", "add Sentry to Deno", "install @sentry/node", "@sentry/bun", or "@sentry/deno", or configure error monitoring, tracing, logging, profiling, metrics, crons, or AI monitoring for server-side JavaScript/TypeScript runtimes.
Full Sentry SDK setup for Android. Use when asked to "add Sentry to Android", "install sentry-android", "setup Sentry in Android", or configure error monitoring, tracing, profiling, session replay, or logging for Android applications. Supports Kotlin and Java codebases.
Full Sentry SDK setup for PHP. Use when asked to "add Sentry to PHP", "install sentry/sentry", "setup Sentry in PHP", or configure error monitoring, tracing, profiling, logging, metrics, or crons for PHP applications. Supports plain PHP, Laravel, and Symfony.