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Found 1,865 Skills
Regulatory variant interpretation -- GWAS association lookup, eQTL analysis, chromatin state annotation, regulatory element overlap, and trait ontology resolution. Connects GWAS Catalog, GTEx, ENCODE, RegulomeDB, OpenTargets, OLS ontology, and Ensembl regulatory features. Use when users ask about non-coding variants, GWAS hits, eQTLs, regulatory elements, enhancer/promoter variants, or trait-associated SNPs.
Step-by-step guide for creating your own Claude Skills, from deciding whether a skill is the right tool to writing the SKILL.md file, structuring reference material, and making it trigger reliably. Use when you want to package a workflow, framework, or repeated task into a reusable Skill, when an existing skill is not triggering or not loading the right context, when you are auditing a skill that is underperforming, or when you want to publish a skill for others. Also triggers when someone asks "how do I make a skill" or "what makes a good skill". Useful for individuals, teams, and anyone publishing skills publicly.
Guides managers out of the bottleneck role — provides the Team Rep pattern, Epic Ownership model, Task-Relevant Maturity framework, kingdom ownership, and three-layer assignment strategy. Use when the user wants to delegate work or says "I'm doing everything," "team isn't taking ownership," "I can't let go," "team rep," "project ownership," "I'm the go-to person," "bus factor," "I work weekends," "how do I delegate," or "engineers don't take initiative." Do NOT use for managing a specific underperformer (use performance-reviews) or deciding what work to prioritize (use roadmap-planning).
Covers both giving and getting feedback — structures and scripts feedback conversations (positive, constructive, or behavioral) and provides techniques for drawing honest feedback from your own team. Produces SBI-framed feedback statements, opening lines for hard conversations, scripts for real situations, ways to handle resistance, and methods for extracting real feedback from reports. Use when the user wants to give someone feedback, says "how do I tell someone," "this person is struggling," "address a behavior," "hard conversation," "someone is underperforming," "praise this person," "write feedback for," "I need to say something," "difficult conversation," "get feedback from my team," "my team won't give me feedback," "blind spots," or "what does my team think of me." Do NOT use for formal annual or performance reviews (use performance-reviews) or sensitive HR situations that go beyond feedback (use difficult-situations).
Evaluate whether figures and plots in a manuscript effectively communicate the claims they support. Audits chart-type fit, axis design, visual hierarchy, data density, caption interpretation, perceptual accuracy, and narrative arc across 8 dimensions. Triggers on: "do my figures work", "check my plots", "are my graphs clear", "figure audit", "do my figures support my claims", "visualization review", "figure rhetoric", "plot review", "chart critique", "visual argument check". Companion to manuscript-review §12 (legibility) and figure-table-quality (rendering).
Guides management consulting-style work—engagement framing, hypothesis-driven problem structuring, issue trees, business cases, operating model and capability design, strategic options analysis, workshop facilitation, and executive recommendations (not legal advice). Use when diagnosing a business problem, structuring a strategy or transformation initiative, building a business case for leadership, designing target operating models, preparing steerCo or board recommendations, or advising on build-vs-buy and portfolio priorities—not for detailed requirements/BRDs (business-analyst), multi-team delivery tracking (technical-program-manager), contract negotiation (commercial-counsel), revenue accounting (senior-revenue-accountant), applied AI architecture (applied-ai-architect-commercial-enterprise), or system ADRs (senior-system-architecture). Canvas/TAM: business-model-researcher. Comms: communication-lead. M&A closing: transaction-manager. M&A principal/IC: transaction-principal.
Guides technical program management for security coordinated vulnerability disclosure (CVD)— disclosure policy, intake and triage SLAs, researcher coordination, fix/remediation tracking, embargo and publication timelines, CVE/advisory coordination, bug bounty program operations, and cross-functional gates (security engineering, legal, comms, product). Use when running a CVD or responsible disclosure program, disclosure calendar, bounty ops, or unblocking multi-team remediation for reported vulnerabilities—not for hands-on pentest (offensive-security-analyst), SOC triage (defensive-security-analyst), vuln scanning in CI (devsecops), enterprise security strategy (cybersecurity), generic non-security programs (technical-program-manager), or contract redlines (commercial-counsel).
Guides actuarial work for insurance and reinsurance—pricing and rate adequacy, reserving and IBNR, loss development and triangles, mortality/morbidity and lapse assumptions, experience studies and credibility, capital and risk metrics at overview level, product design tradeoffs (life, health, P&C, annuity), and regulatory reporting concepts (NAIC, IFRS 17, Solvency II overview—not legal advice). Use when the user mentions actuary, actuarial, IBNR, loss development, reserve analysis, mortality table, pricing insurance, experience study, IFRS 17, loss ratio, combined ratio, credibility, or asks for assumption documentation and model governance for insurance products—not generic FP&A (financial-analyst), investment banking valuation (comps-analysis, dcf-model), legal policy interpretation (commercial-counsel), clinical trials, software-only implementation (senior-software-engineer), or broad GRC without actuarial models (compliance-engineer).
Guides identity and access management—workforce and machine identity lifecycle, RBAC/ABAC/PBAC entitlement design, access reviews and recertification, SSO/SAML/OIDC federation, privileged access (PAM/JIT), cloud IAM least privilege (AWS/GCP/Azure concepts), service accounts and secrets hygiene, and separation of duties. Use for IAM, identity governance, access review, RBAC, least privilege, SSO federation, PAM, privileged access, cloud IAM policy, service account, or SoD—not full cloud landing zone architecture (enterprise-cloud-architect), broad cloud security controls (cloud-security-engineer), day-2 break-glass ticket execution only (cloud-system-administrator), pentest (penetration-tester), or legal/HR policy drafting only.
Guides engineering of multi-agent systems—agent roles and specialization, orchestration topologies (supervisor, peer-to-peer, hierarchical, blackboard), task decomposition and routing, inter-agent messaging (A2A-style patterns), shared vs partitioned state, fan-out/fan-in and DAG workflows, synchronization and consensus, conflict resolution, fault tolerance and retries across agents, cost/latency/token budgets, cross-agent observability, testing multi-agent flows, and deployment (queues, durable workflows). Framework-agnostic; high-level LangGraph, Deep Agents, and agenthub—not single-agent loops (agentic-ai-developer), ML training (ai-engineer), strategy-only whiteboard (enterprise-strategist), or PM planning (technical-program-manager). Use for multi-agent system, multi-agent engineer, agent orchestration, supervisor agent, agent topology, fan-out fan-in, agent handoff protocol, multi-agent workflow, agent coordination, blackboard pattern, hierarchical agents, A2A, agent DAG, multi-agent architecture.
Guides property and casualty (P&C) insurance—commercial and personal lines, major LOBs (property, GL, workers comp, commercial auto, umbrella, specialty), underwriting and risk selection, policy triggers (occurrence vs claims-made), limits and exclusions, claims (FNOL, reserving, litigation), reinsurance and catastrophe, distribution (agents, brokers, MGAs), metrics (loss ratio, combined ratio, cat load), and state DOI/rate filing overview—not legal advice. Use for P&C insurance, property and casualty, commercial lines, workers comp, general liability, combined ratio, loss ratio, underwriting, claims-made, occurrence policy, reinsurance, catastrophe, MGA, rate filing, or FNOL—not actuarial modeling (actuary), life/health depth, legal interpretation (commercial-counsel), or GRC controls without insurance context (compliance-engineer).
Guides supply chain management—sourcing and supplier qualification, procurement and PO governance, demand forecasting and inventory policy, logistics and fulfillment (3PL, Incoterms, lead times), supplier scorecards, cost and TCO analysis, supply risk and continuity, and SCM KPI dashboards. Use when designing supply strategy, running RFQs, setting safety stock, resolving stockouts or excess inventory, improving OTIF, dual-sourcing critical parts, or building supplier business reviews—not for contract legal redlines (commercial-counsel), vendor security assessments (information-security-engineer), DC construction delivery programs (senior-data-center-capacity-delivery-manager), compute GL and invoice reconciliation (compute-accounting-manager), SaaS quote-to-order (deal-operations-administrator), or enterprise strategy cases (business-consultant).