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Found 352 Skills
Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.
Debug Node.js/TypeScript/JavaScript applications using the agent-dbg CLI debugger. Use when: (1) investigating runtime bugs by stepping through code, (2) inspecting variable values at specific execution points, (3) setting breakpoints and conditional breakpoints, (4) evaluating expressions in a paused context, (5) hot-patching code without restarting, (6) debugging test failures by attaching to a running process, (7) any task where understanding runtime behavior requires a debugger. Triggers: "debug this", "set a breakpoint", "step through", "inspect variables", "why is this value wrong", "trace execution", "attach debugger", "runtime error".
Perl text processing and scripting with regular expressions. Use for .pl files.
Fiber Express-inspired Go web framework. Use for Go APIs.
Learn and write templ component syntax including expressions, conditionals, loops, and Go integration. Use when writing .templ files, learning templ syntax, or mentions 'templ component', 'templ expressions', or '.templ file syntax'.
Generic tRPC implementation guide. Works with any framework (Next.js, Express, Fastify, Hono, Bun) and any package manager (pnpm, npm, yarn, bun).
Walk Claude through PyDESeq2-based differential expression, including ID mapping, DE testing, fold-change thresholding, and enrichment visualisation.
Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and integration with single-cell data. Use when analyzing spatial transcriptomics datasets, studying tissue organization, identifying spatial expression patterns, mapping cell-cell interactions in tissue context, characterizing tumor microenvironment spatial structure, or integrating spatial and single-cell RNA-seq data for comprehensive tissue analysis.
Use when ANY runtime debugging is needed — setting breakpoints, inspecting variables, evaluating expressions, analyzing threads, or reproducing crashes interactively with LLDB
Work with ISML templates in B2C Commerce. Use when writing storefront templates, using isprint/isset/isloop tags, understanding ISML expressions (${...}), or creating custom template modules. Covers tag syntax, expression language, and template includes.
Use when you need to apply functional programming principles in Java — including writing immutable objects and Records, pure functions, functional interfaces, lambda expressions, Stream API pipelines, Optional for null safety, function composition, higher-order functions, pattern matching for instanceof and switch, sealed classes/interfaces for controlled hierarchies, Stream Gatherers for custom operations, currying/partial application, effect boundary separation, and concurrent-safe functional patterns. Part of the skills-for-java project
NestJS framework best practices and production patterns. Use whenever working with NestJS — creating modules, controllers, services, DTOs, guards, interceptors, pipes, middleware, or building REST/GraphQL/microservice APIs. Also use when setting up authentication, authorization, validation, queues, health checks, WebSockets, caching, or any @nestjs/* package. Even for simple NestJS tasks, this skill ensures correct import paths, proper decorator usage, and production-ready patterns. Covers NestJS v11 with Express v5, native JWT auth, Zod validation, Keyv caching, and Suites testing.