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Found 301 Skills
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Use this skill when implementing data validation, data quality monitoring, data lineage tracking, data contracts, or Great Expectations test suites. Triggers on schema validation, data profiling, freshness checks, row-count anomalies, column drift, expectation suites, contract testing between producers and consumers, lineage graphs, data observability, and any task requiring data integrity enforcement across pipelines.
Constructive critique through 5 HackerNews commenter personas with evidence-based claim validation. Use when user wants devil's advocacy, stress testing, or critical review of ideas, docs, architecture, or code. Use for "roast", "critique this", "poke holes", "devil's advocate", "stress test", or "what's wrong with". Do NOT use for code review (use systematic-code-review), implementation changes, or performance profiling without a specific critique request.
Create Docker containers for Huawei Ascend NPU development with proper device mappings and volume mounts. Use when setting up Ascend development environments in Docker, running CANN applications in containers, or creating isolated NPU development workspaces. Supports privileged mode (default), basic mode, and full mode with profiling/logging. Auto-detects available NPU devices.
How to benchmark and analyze memory usage in Turso using the memory-benchmark crate and dhat heap profiler. Use this skill whenever the user mentions memory usage, memory profiling, allocation tracking, heap analysis, memory regression, memory benchmarking, dhat, or wants to understand where memory is being allocated during SQL workloads. Also use when investigating memory growth in WAL or MVCC mode. IMPORTANT - If you modify the perf/memory crate (add profiles, change CLI flags, change output format, etc.), update this skill document to reflect those changes so it stays accurate for future agents.
Full Sentry SDK setup for React. Use when asked to "add Sentry to React", "install @sentry/react", or configure error monitoring, tracing, session replay, profiling, or logging for React applications. Supports React 16+, React Router v5-v7 non-framework mode, TanStack Router, Redux, Vite, and webpack.
Guides Site Reliability Engineering—SLI/SLO and error budgets, reliability dashboards and burn-rate alerting, production readiness reviews, capacity planning for availability, toil reduction, dependency and failure-mode analysis, release reliability (canaries, rollback criteria), and service-owner incident mitigation tied to customer impact. Use when defining or operating SLOs, measuring error budget burn, improving service reliability, running PRRs before launch, planning scalable resilient capacity, or leading technical mitigation during outages—not for CI/CD pipeline implementation (devops), incident program and paging policy design (incident-management-engineer), cloud access and patch tickets (cloud-system-administrator), load-test profiling (performance-engineer), rollout cutover strategy (deployment-strategist), or greenfield cloud build-out (cloud-engineer).
Guide for adding a new benchmark or training environment to NeMo-Gym. Use when the user asks to add, create, or integrate a benchmark, evaluation, training environment, or resources server into NeMo-Gym. Also use when wrapping an existing 3rd-party benchmark library. Covers the full workflow: data preparation, resources server implementation, agent wiring, YAML config, testing, and reward profiling (baselining). Triggered by: "add benchmark", "new resources server", "integrate benchmark", "wrap benchmark", "add training environment", "add eval".
Use when adding new resource tracking types to memory profiling in developtools_profiler and third_party_musl repositories. Triggered by requests to add trace tags, resource labels, or memory tracking types.
Performance optimization guidance for .NET MAUI apps covering profiling, compiled bindings, layout efficiency, image optimization, resource dictionaries, startup time, trimming, and NativeAOT configuration. USE FOR: "performance optimization", "slow startup", "app performance", "compiled bindings", "layout optimization", "image optimization", "trimming", "NativeAOT", "profiling MAUI", "reduce app size", "startup time". DO NOT USE FOR: data binding syntax (use maui-data-binding), deprecated API migration (use maui-current-apis), or unit testing setup (use maui-unit-testing).
Full Sentry SDK setup for PHP. Use when asked to "add Sentry to PHP", "install sentry/sentry", "setup Sentry in PHP", or configure error monitoring, tracing, profiling, logging, metrics, or crons for PHP applications. Supports plain PHP, Laravel, and Symfony.
Shared optimization guidance plus cuTile Python DSL-specific overlays. Use when: (1) selecting optimizations for a cuTile Python DSL kernel, (2) checking cuTile-specific implementation traps, (3) deciding whether a profiling finding belongs in shared knowledge or a cuTile overlay, (4) updating cuTile Python DSL optimization docs, (5) reviewing how a shared pattern maps to cuTile.