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Found 213 Skills
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Optimizes ClickHouse queries for speed and efficiency. Helps with primary key design, sparse indexes, data skipping indexes (minmax, set, bloom filter, ngrambf_v1), partitioning strategies, projections, PREWHERE optimization, approximate functions, and query profiling with EXPLAIN. Use when writing ClickHouse queries, designing table schemas, analyzing slow queries, or implementing analytical aggregations. Works with columnar OLAP workloads.
Debug Flutter applications systematically with this comprehensive troubleshooting skill. Covers RenderFlex overflow errors, setState() after dispose() issues, null check operator failures, platform channel problems, build context errors, and hot reload failures. Provides structured four-phase debugging methodology with Flutter DevTools, widget inspector, performance profiling, and platform-specific debugging for Android, iOS, and web targets.
Debug Angular applications systematically with expert-level diagnostic techniques. This skill provides comprehensive guidance for troubleshooting dependency injection errors, change detection issues (NG0100), RxJS subscription leaks, lazy loading failures, zone.js problems, and common Angular runtime errors. Includes structured four-phase debugging methodology, Angular DevTools usage, console debugging utilities (ng.probe), and performance profiling strategies for modern Angular applications.
Debug SwiftUI application issues systematically. This skill helps diagnose and resolve SwiftUI-specific problems including view update failures, state management issues with @State/@Binding/@ObservedObject, NavigationStack problems, memory leaks from retain cycles, preview crashes, Combine publisher issues, and animation glitches. Provides Xcode debugger techniques, Instruments profiling, and LLDB commands for iOS/macOS development.
Debug TensorFlow and Keras issues systematically. This skill helps diagnose and resolve machine learning problems including tensor shape mismatches, GPU/CUDA detection failures, out-of-memory errors, NaN/Inf values in loss functions, vanishing/exploding gradients, SavedModel loading errors, and data pipeline bottlenecks. Provides tf.debugging assertions, TensorBoard profiling, eager execution debugging, and version compatibility guidance.
Master Dart/Flutter performance optimization including efficient code patterns, data structure selection, and compilation benefits.
Guidance for interpreting SPAA (Stack Profile for Agentic Analysis) files. Provides information on the file format, as well as tips on how to use it to identify performance bottlenecks, memory leaks, or opportunities for optimization. Use when the user is trying to read a .spaa file to understand the performance of an application.
Establish CPU/GPU baselines before resource-intensive operations.