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Found 1,248 Skills
Identify and prioritize causal variants at GWAS loci using statistical fine-mapping and locus-to-gene predictions. Computes posterior probabilities for causal variants, links variants to genes via L2G predictions, annotates functional consequences, and suggests validation strategies. Use when asked to fine-map GWAS loci, prioritize causal variants, identify credible sets, or link GWAS signals to causal genes.
Guide for using direnv - a shell extension for loading directory-specific environment variables. Use when setting up project environments, creating .envrc files, configuring per-project environment variables, integrating with Python/Node/Ruby/Go layouts, working with Nix flakes, or troubleshooting environment loading issues on macOS and Linux.
Generate mathematically accurate color palettes using OKLCH color space. Use when creating design systems, color ramps, accessible palettes, CSS variables for themes, or when user asks about color generation.
WCAG AA and ARIA best practices — screen readers, keyboard navigation, focus management. Use when building any user-facing interface or reviewing accessibility compliance.
This skill should be used when the user asks "how do I customize Bootstrap", "how to create a custom Bootstrap theme", "what Sass variables can I override", "how to implement dark mode in Bootstrap", "how to change Bootstrap colors", "how to override Bootstrap defaults", "how to add custom colors to Bootstrap", "how to enable Bootstrap shadows", "how to compile Bootstrap Sass", "how to use Bootstrap CSS variables", or needs help with Bootstrap theming, Sass variable overrides, CSS custom properties, or color mode implementation.
Adversarially test a thesis or take for differentiation, robustness, and blind spots. Prevents publishing consensus as contrarian and surfaces what would change your mind.
Deploys a Next.js or Vite project to Vercel, pushes all environment variables from .env.local to production, adds a SPA rewrite rule for Vite, and updates the Supabase site_url to the live domain. Called by the vibe-ship orchestrator.
Applies best practices for logging, project structure, and environment variable usage specifically to the main application file.
Configure Aspire AppHost to emit explicit app config via environment variables; keep app code free of Aspire clients and service discovery.
Better environment variable management for agents and humans with full type safety, CLI-based remote environment synchronization, and environment validation. Use when setting up typed config schemas, validating env variables, or managing remote env vars across Vercel, Netlify, Railway, Cloudflare, and Fly.io with better-env.
Asset allocation frameworks: strategic (SAA), tactical (TAA), mean-variance optimization, Black-Litterman, risk parity, glide paths.
Use when setting up SOPS + age encryption for environment variables. Checks dependencies, creates config, copies scripts, and adds package.json commands. Triggers on: setup sops, setup env encryption, add age encryption, env:pull, env:push.