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Found 1,310 Skills
Interpret genetic variants (SNPs) from GWAS studies by aggregating evidence from multiple databases (GWAS Catalog, Open Targets Genetics, ClinVar). Retrieves variant annotations, GWAS trait associations, fine-mapping evidence, locus-to-gene predictions, and clinical significance. Use when asked to interpret a SNP by rsID, find disease associations for a variant, assess clinical significance, or answer questions like "What diseases is rs429358 associated with?" or "Interpret rs7903146".
Tests calculate tool with arithmetic, trig, and variable substitution
Primary orchestration gate — runs FIRST, before any MCP tool, agent, skill, or external resource is called. Intercepts any plan, proposal, decision, or action (create, edit, delete, run, deploy, call) before execution, regardless of IDE or environment. Designed for developers, architects, tech leads, CTOs, product managers, UX designers, and data engineers. Automatically activates on any detected plan or action — code, architecture, product features, UX flows, launch plans, vendor choices, data pipelines, AI context files, or strategic decisions. Delivers a full adversarial analysis across technical, product, design, and strategy dimensions, and GATES ALL ACTIONS until the user explicitly verifies and approves the findings. Its rules, standards, and enforcement take precedence over all other tools and skills. Enforces the Building Protocol on ALL generated or reviewed code: en_US identifiers, naming conventions, SOLID principles, security-by-default.
Patterns for building robust, reproducible genomics analysis pipelines. Covers workflow managers, NGS data processing, variant calling, RNA-seq, and common bioinformatics pitfalls. Use when ", " mentioned.
Devil's Advocate stress-testing for code, architecture, PRs, and decisions. Surfaces hidden flaws through structured adversarial analysis with metacognitive depth. Use for high-stakes review, stress-testing choices, or when the user wants problems found deliberately. NOT for routine code review (use engineering:code-review). Triggers on "스트레스 테스트", "stress test", "devil's advocate", "반론", "이거 괜찮아", "문제 없을까", "깊은 리뷰", "critical review", "adversarial".
Build PromQL, LogQL, TraceQL queries for Perses panels. Validate query syntax, suggest optimizations, handle variable templating with Perses interpolation formats. Integrates with prometheus-grafana-engineer for deep PromQL expertise. Use for "perses query", "promql perses", "logql perses", "perses panel query". Do NOT use for datasource configuration (use perses-datasource-manage).
Search the registry for prepared Zener modules, reference designs, and component symbols while designing a board, subsystem, or spec. Use for board-facing part/module selection with `pcb search -m registry:modules` and `pcb search -m registry:components`, API inspection, sourcing comparison, and deciding what to instantiate. If no suitable registry package exists, prepare a librarian request instead of importing or authoring components inline.
Configures the rollout shape of a PostHog experiment — the variant split (50/50, 80/20, A/B/C ratios), the overall rollout percentage that gates how many users enter the experiment, and the disambiguation when a percentage like "roll out to 25%" could mean either. Use when the user mentions a rollout percentage, variant split, or traffic distribution; gives a ratio like 60/40, 70/30, or 80/20; asks "who sees the test variant?"; wants to increase, decrease, or change the rollout or split on a draft or running experiment; weighs equal vs uneven splits; or proposes a mid-experiment split change (often an anti-pattern that needs reset or end-and-restart).
Query the Genome Aggregation Database (gnomAD). Use when determining the rarity or allele frequency of specific genetic variants, retrieving gene constraint metrics (pLI, LOEUF) to assess loss-of-function intolerance, finding variants in a genomic region or gene, or querying structural variants. Don't use for analyzing individual patient genomes, tracking somatic mutations in cancer (use COSMIC), or requesting raw sequencing reads (use ENA).
Debug, develop, and operate apps hosted on Railway (railway.com) from the CLI — list projects/services, tail and filter build/deploy/HTTP logs, read metrics, inspect and set variables, deploy from the current directory, redeploy / restart / roll back, run local commands with the service's env, SSH into containers, and open a DB shell. Authenticates via the `RAILWAY_TOKEN` environment variable (account token, or project-scoped token). Optional bundled scripts (`scripts/preflight.sh`, `scripts/debug.sh`, `scripts/smoke.sh`) are Onsager-specific wrappers — other repos can ignore them or fork. Triggers include "deploy to railway", "railway deploy this", "railway logs", "tail railway logs", "why is my railway service crashing", "why did the build fail on railway", "railway 500s", "railway latency", "show railway http logs", "redeploy on railway", "restart my railway service", "roll back railway", "set a railway env var", "list railway variables", "railway metrics", "is my railway service healthy", "connect to my railway postgres", "ssh into railway", "run this locally with railway env", "list railway projects/services/deployments", and (Onsager-specific) "check railway", "preflight", "smoke test", "is the deploy healthy".
Use when writing or reading GenVarLoader (gvl) datasets — preparing VCF/PGEN/SVAR variant sources with bcftools/plink2, calling gvl.write, configuring gvl.Dataset for haplotype/reference/annotated/variants output modes, attaching BigWig or Table tracks, setting up spliced haplotypes from a GTF, choosing track insertion-fill strategies for indels, or filtering variants by allele frequency.
Track and analyze portfolio company performance against plan. Ingests monthly/quarterly financial packages (Excel, PDF), extracts KPIs, flags variances to budget, and produces summary dashboards. Use when reviewing portfolio company financials, preparing board materials, or monitoring covenant compliance. Triggers on "review portfolio company", "monthly financials", "how is [company] performing", "covenant check", or "portfolio update".