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Found 5,385 Skills
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.
Joel's writing voice and style guide for joelclaw.com content. Use when writing, editing, or reviewing any blog post, essay, book chapter, or prose content for joelclaw.com. Also use when asked to 'write like Joel,' 'match Joel's voice,' 'draft a post,' 'write content for the blog,' or 'review this for voice.' This skill captures Joel's specific writing patterns derived from ~90,000 words of published content spanning 2012–2026. Cross-reference with copy-editing and copywriting skills for marketing-specific copy.
Comprehensive guidelines for designing, writing, and implementing effective notification systems across email, push, SMS, in-app, and chat channels.
Create and use brand.yml files for consistent branding across Shiny apps and Quarto documents. Use when working with brand styling, colors, fonts, logos, or corporate identity in Shiny or Quarto projects. Covers: (1) Creating new _brand.yml files from brand guidelines, (2) Applying brand.yml to Shiny for R apps with bslib, (3) Applying brand.yml to Shiny for Python apps with ui.Theme, (4) Using brand.yml in Quarto documents, presentations, dashboards, and PDFs, (5) Modifying existing brand.yml files, (6) Troubleshooting brand integration issues. Includes complete specifications and framework-specific integration guides.
Create implementation plans with tasks grouped by subsystem. Related tasks share agent context; groups parallelize across subsystems.
Convert local documents to Markdown using Microsoft's markitdown CLI. Best for: PDF, Word, Excel, PowerPoint, images (OCR), audio. Can fetch URLs but Jina is faster for web. Triggers on: convert to markdown, read PDF, parse document, extract text from, docx, xlsx, pptx, OCR image, local file.
Convert a course outline into a fully fleshed out intelligent textbook. Use when: (1) User provides a URL containing a course outline/syllabus (2) User asks to "generate a course" or "create a textbook" from an outline (3) User wants to expand a course description into full learning materials Generates: learning graph, chapter structure, MicroSim specifications, quizzes, glossary, and FAQ following the intelligent textbooks framework and evidence-based learning design principles.
Generate and evaluate marketing slogans for any product or service. Creates options across multiple angles, scores against criteria, and recommends the best fit.
Manage project todos in todo.md files with task states (pending, in_progress, completed). PROACTIVELY invoke when Claude detects need to create or update a todo during a session. Use when breaking down work into tasks, tracking progress across sessions, organizing complex multi-step projects, or coordinating task states. Supports refactor/migration tracking with ADR integration.
Discover existing shadcn components from registries before building custom. Use PROACTIVELY when about to build any UI component, page section, or layout. Use when user explicitly asks to find/search components. Searches 1,500+ components across official and community registries including @shadcn, @blocks, @reui, @animate-ui, @diceui, Magic UI, and 30+ specialty registries. Provides install commands and code examples. Works best with shadcn MCP configured, but provides manual guidance without it.
Write effective microcopy for user interfaces. Trigger with "write copy for", "help with UX copy", "what should this button say", "error message for", "empty state copy", or when the user needs help with any interface text.
Odoo 17.0 full-stack development skill for AI agents. Covers backend module architecture, ORM models and fields, API decorators, recordset operations, actions, performance patterns, testing, and built-in mixins. Use when building, extending, or debugging Odoo 17.0 custom modules. Triggers on tasks involving __manifest__.py, models.Model, @api decorators, XML views, ir.actions, ir.cron, mail.thread, or any Odoo 17.0 framework pattern.