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Found 9,234 Skills
AI-driven patient-to-trial matching for precision medicine and oncology. Given a patient profile (disease, molecular alterations, stage, prior treatments), discovers and ranks clinical trials from ClinicalTrials.gov using multi-dimensional matching across molecular eligibility, clinical criteria, drug-biomarker alignment, evidence strength, and geographic feasibility. Produces a quantitative Trial Match Score (0-100) per trial with tiered recommendations and a comprehensive markdown report. Use when oncologists, molecular tumor boards, or patients ask about clinical trial options for specific cancer types, biomarker profiles, or post-progression scenarios.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
Research historical and cultural background of Bible passages. Use when exploring authorship, original audience, dating, archaeology, geography, political-socio-economic context, social norms, or external historical sources related to Scripture.
Manage Slot teams, billing, credits, and collaborators.
Automatically generate mobile-first responsive CSS/SCSS when creating component styles or mentioning responsive design. Implements standard breakpoints (768px, 1024px), ensures WCAG AA color contrast, creates touch-friendly interfaces (44px minimum targets), adds proper focus indicators, supports reduced motion, scales typography responsively, and provides detailed technical specifications with exact values.
Perform security-focused review of code diffs and pull requests, identifying newly introduced vulnerabilities, security regressions, and unsafe patterns in changed code.
Foundational EVM integration for AAVE-related scripts using viem. Use when user asks to read balances, read/write contracts, send transactions, or set up typed viem clients for Ethereum and Arbitrum.
Generate security fixes from detect-dev findings with regression tests. Use when remediating security vulnerabilities.
Performs comprehensive security audits of KrakenD configurations to identify vulnerabilities, authentication gaps, and security best practices violations with Flexible Configuration support
Handles keyboard, mouse, and custom events in Textual applications using messages and handlers. Use when implementing keyboard bindings, custom message passing, event bubbling, action dispatch, and inter-widget communication. Covers event handling patterns, message definitions, and routing.
Implements conditional visibility for Home Assistant dashboard cards using state, numeric_state, screen, user, time, and/or conditions via Conditional Card wrapper and per-card visibility property. Use when asked to "hide card when", "show only if", "user-specific dashboard", "mobile vs desktop cards", "conditional visibility", or "show card based on state/time/user".