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Found 5,565 Skills
A skill that provides weather information based on reference data.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Design experiment plans with progressive stages — initial implementation, baseline tuning, creative research, and ablation studies. Plan baselines, datasets, hyperparameter sweeps, and evaluation metrics. Use when planning experiments for a research paper.
Revise papers based on reviewer feedback. Map reviewer concerns to specific sections, apply targeted edits, run additional experiments if needed, and verify improvements. Use after receiving peer review with revision requests.
Performance attribution: Brinson (allocation/selection/interaction), factor-based attribution, fixed-income attribution.
Upstream codebase exploration for open source contribution. Outputs contribution guidelines, PR patterns, and maintainer expectations. Triggers: "pr research", "upstream research", "contribution research", "explore upstream repo".
Review code according to Drupal's official coding standards. Provides AI agents with comprehensive guidelines for PHP, JavaScript, CSS, Twig, YAML, SQL, and markup files in Drupal projects. Uses dynamic context discovery to load only relevant standards based on file type being reviewed.
Creates optimized meta titles, descriptions, and URL suggestions based on character limits and best practices. Generates compelling, keyword-rich metadata. Use PROACTIVELY for new content.
Interpret genetic variants (SNPs) from GWAS studies by aggregating evidence from multiple databases (GWAS Catalog, Open Targets Genetics, ClinVar). Retrieves variant annotations, GWAS trait associations, fine-mapping evidence, locus-to-gene predictions, and clinical significance. Use when asked to interpret a SNP by rsID, find disease associations for a variant, assess clinical significance, or answer questions like "What diseases is rs429358 associated with?" or "Interpret rs7903146".
Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and integration with single-cell data. Use when analyzing spatial transcriptomics datasets, studying tissue organization, identifying spatial expression patterns, mapping cell-cell interactions in tissue context, characterizing tumor microenvironment spatial structure, or integrating spatial and single-cell RNA-seq data for comprehensive tissue analysis.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Bytecode interpreter and JIT compiler skill for implementing language runtimes in C/C++. Use when designing bytecode dispatch loops (switch, computed goto, threaded code), implementing stack-based or register-based VMs, adding a simple JIT using mmap/mprotect, or understanding performance trade-offs in interpreter design. Activates on queries about bytecode VMs, dispatch loops, computed goto, JIT compilation basics, tracing JITs, or implementing a scripting language runtime.