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Found 443 Skills
Connect GWAS variants to biological pathways for drug target discovery. Maps disease-associated SNPs to causal genes via eQTL colocalization (GTEx), links genes to enriched pathways (Reactome, KEGG, MetaCyc), and identifies druggable targets within disease-relevant pathways. Use when asked to translate GWAS findings into mechanistic insights, find pathways enriched for disease genes, discover drug targets from genetic evidence, or answer questions like "What pathways are disrupted in type 2 diabetes based on GWAS data?"
Analyze HLA genes, MHC binding, epitope-MHC associations, and immunogenomics for transplant compatibility, vaccine design, and immunotherapy. Integrates IMGT, IEDB, BVBRC, UniProt, and DGIdb. Use for HLA typing interpretation, antigen presentation analysis, MHC restriction, neoantigen prediction context, and transplant immunology.
Deterministic feedback processor. Fetches client feedback emails from Gmail, downloads attachments (screenshots), and prepares a structured report for triaging into GitHub issues.
Optimize and prepare figures for arXiv submission: format conversion (EPS/PDF/PNG/JPG), size reduction, metadata stripping, processor compatibility (DVI vs PDFLaTeX). Triggers on: "optimize figures for arXiv", "reduce figure size", "convert figures for arXiv", "fix arXiv figures", "figure too large", "arxiv image compression". Companion to arxiv-preflight and arxiv-package.
Gain wisdom from setbacks — Go through the 5-step interactive reflection (Setback → Automatic Output → Old Weights → New Parameters → Alternative Action), move from "emotional review" to "behavioral training", and update the L3 weights of your first reactions. Use when Wang Jianshuo reflects on a personal setback, mistake, or recurring pattern (reflection, post-mortem review, review, draw lessons, learn from a setback, gain wisdom, "I messed up again", "Why does this keep happening?", "Why do I always…?", "I can't just let it go", "I know the principles but can't put them into practice"). For the user as a human, not for Claude's task post-mortems.
Student semester onboarding — clinic procedures, tool walkthrough, practice exercises before real cases. Reads the handbook the professor uploaded at setup and teaches it interactively. Use when a new clinic student says "onboard me", "I'm new to the clinic", "getting started", or at the start of each semester; pass --card for the one-page reference.
Adds tracing, telemetry, and observability to an assistant-ui backend. Use when wiring an AI SDK route handler (streamText/generateText, toUIMessageStreamResponse) to a tracing backend: Langfuse via OpenTelemetry (LangfuseSpanProcessor and NodeSDK in instrumentation.ts, experimental_telemetry isEnabled, propagateAttributes with traceName/userId/sessionId, langfuseSpanProcessor.forceFlush on serverless), LangSmith via wrapAISDK(ai) from langsmith/experimental/vercel (createLangSmithProviderOptions, awaitPendingTraceBatches), or Helicone via createOpenAI baseURL https://oai.helicone.ai/v1 with the Helicone-Auth header. Also covers rendering collected spans with @assistant-ui/react-o11y headless primitives (SpanResource, SpanPrimitive Root/Indent/CollapseToggle/StatusIndicator/TypeBadge/Name/Children, SpanByIndexProvider, SpanData/SpanState) mounted via useAui/AuiProvider from @assistant-ui/store. Use for missing or empty traces, edge vs nodejs runtime telemetry, serverless flush issues, or trace waterfalls.
Comprehensive immune repertoire analysis for T-cell and B-cell receptor sequencing data. Analyze TCR/BCR repertoires to assess clonality, diversity, V(D)J gene usage, CDR3 characteristics, convergence, and predict epitope specificity. Integrate with single-cell data for clonotype-phenotype associations. Use for adaptive immune response profiling, cancer immunotherapy research, vaccine response assessment, autoimmune disease studies, or repertoire diversity analysis in immunology research.
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Rapid Symfony admin panel development with EasyAdminBundle. Capabilities: CRUD generation, dashboard creation, entity management, form customization, menu configuration, field configuration, action customization, filters, permissions, batch actions, custom themes, file uploads, image handling, associations, submenus, custom queries, event listeners. Use for: admin panels, backend interfaces, content management, data administration, CRUD operations, user management, product catalogs, blog administration, e-commerce backends. Triggers: easyadmin, symfony admin, crud, admin panel, dashboard, backend, entity crud, admin interface, symfony backend, easyadmin, easyadmin bundle, admin generator, backend panel
Finds all REFACTOR markers in codebase, validates associated ADRs exist, identifies stale markers (30+ days old), and detects orphaned markers (no ADR reference). Use during status checks, before feature completion, or for refactor health audits. Triggers on "check refactor status", "marker health", "what's the status", or PROACTIVELY before marking features complete. Works with Python (.py), TypeScript (.ts), and JavaScript (.js) files using grep patterns to locate markers and validate against ADR files in docs/adr/ directories.
Speech and sharing coach. Based on the *How to Speak* methodology of Patrick Winston (MIT AI professor), it helps users prepare for speech scenarios including offline training, technical sharing, Bilibili tutorial videos, etc. This skill is applicable when users mention "speech", "sharing", "training", "lecture", "PPT speech", "opening", "closing", "how to speak", "speech structure".