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Found 1,244 Skills
Systematic ACMG/AMP variant classification using ToolUniverse tools. Given a genetic variant (HGVS, rsID, or gene+change), applies all 28 ACMG criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) through automated database queries and computational predictions. Produces a final 5-tier classification (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with evidence summary. Use when asked to classify a variant, interpret a VUS, apply ACMG criteria, assess pathogenicity, or determine clinical significance of a germline variant.
Regulatory variant interpretation -- GWAS association lookup, eQTL analysis, chromatin state annotation, regulatory element overlap, and trait ontology resolution. Connects GWAS Catalog, GTEx, ENCODE, RegulomeDB, OpenTargets, OLS ontology, and Ensembl regulatory features. Use when users ask about non-coding variants, GWAS hits, eQTLs, regulatory elements, enhancer/promoter variants, or trait-associated SNPs.
Write flux commentary for every P&L and balance-sheet line over threshold — current vs prior period and vs budget, with the driver explained from underlying activity. Use for the month-end close package and management reporting.
Adversarial code review that breaks the self-review monoculture. Use when you want a genuinely critical review of recent changes, before merging a PR, or when you suspect Claude is being too agreeable about code quality. Forces perspective shifts through hostile reviewer personas that catch blind spots the author's mental model shares with the reviewer.
Guides hands-on actuarial analyst work for insurance, reinsurance, and pension—reserving and loss development (IBNR, triangles, chain-ladder diagnostics), pricing and rate indication support (experience, trend, credibility, basic GLM at spec level), data validation and model I/O review, reporting packs and workpapers, assumption application under actuary direction, and statutory tie-outs at analyst depth. Use when the user mentions actuarial analyst, loss development, IBNR, reserve analysis, rate indication, pricing support, actuarial workpaper, triangle analysis, credibility, experience study, actuarial reporting, or reserve roll-forward—not actuary sign-off (actuary), consulting engagements (actuarial-consulting), assumption governance (assumption-setting), ALM strategy (asset-liability-management), P&C legal depth (property-casualty-insurance), charts only (data-visualization), or ETL-only pipelines (data-scrubbing).
Guides advanced long-term actuarial mathematics (SOA ALTAM)—survival models, life insurance and annuity APVs, premiums and reserves (equivalence principle, Thiele), multiple decrement and Markov states, yield-curve discounting, mortality improvement, longevity risk, profit testing, and mortality graduation. Tool-agnostic, concept-first. Use when the user mentions advanced long-term actuarial mathematics, ALTAM, survival model, life insurance reserve, annuity valuation, equivalence principle, Thiele equation, multiple decrement, force of mortality, longevity risk, mortality improvement, actuarial present value, or net premium reserve—not ASTAM/P&C (advanced-short-term-actuarial-mathematics), workpapers only (actuarial-analyst), appointed actuary (appointed-chief-actuary), assumption governance (assumption-setting), ALM detail (asset-liability-management), or exam-only deliverables.
Guides advanced short-term actuarial mathematics aligned with SOA ASTAM and P&C/health-adjacent modeling—severity and frequency distributions, aggregate and compound loss models, Bühlmann and Bühlmann-Straub credibility, ratemaking and experience rating, short-term reserving at the math level, MLE and goodness-of-fit, and risk measures (VaR, TVaR). Tool-agnostic and concept-first. Use when the user mentions advanced short-term actuarial mathematics, ASTAM, severity model, frequency model, aggregate loss, compound distribution, Bühlmann credibility, experience rating, ratemaking, pure premium, negative binomial frequency, tail factor, TVaR, or short-term actuarial models—not life contingencies (life-health-insurance), Excel workpapers only (actuarial-analyst), appointed actuary sign-off (actuary, appointed-chief-actuary), assumption governance (assumption-setting), P&C legal/operations depth (property-casualty-insurance), or general ML (data-scientist, quantitative-researcher).
Fan out 50+ ad variants from one hero image.
Compares actual spend and revenue against forecasts. Provides variance analysis and corrective insights to ensure financial discipline.
Comprehensive structural variant (SV) analysis skill for clinical genomics. Classifies SVs (deletions, duplications, inversions, translocations), assesses pathogenicity using ACMG-adapted criteria, evaluates gene disruption and dosage sensitivity, and provides clinical interpretation with evidence grading. Use when analyzing CNVs, large deletions/duplications, chromosomal rearrangements, or any structural variants requiring clinical interpretation.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.