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Found 5,502 Skills
Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and integration with single-cell data. Use when analyzing spatial transcriptomics datasets, studying tissue organization, identifying spatial expression patterns, mapping cell-cell interactions in tissue context, characterizing tumor microenvironment spatial structure, or integrating spatial and single-cell RNA-seq data for comprehensive tissue analysis.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Analyze mass spectrometry proteomics data including protein quantification, differential expression, post-translational modifications (PTMs), and protein-protein interactions. Processes MaxQuant, Spectronaut, DIA-NN, and other MS platform outputs. Performs normalization, statistical analysis, pathway enrichment, and integration with transcriptomics. Use when analyzing proteomics data, comparing protein abundance between conditions, identifying PTM changes, studying protein complexes, integrating protein and RNA data, discovering protein biomarkers, or conducting quantitative proteomics experiments.
Design, refactor, and review Effector state management using modern v23+ patterns. Use when tasks involve createStore/createEvent/createEffect modeling, dataflow with sample/attach/split, scope-safe SSR with fork/allSettled/serialize/hydrate, React integration with useUnit, Solid/Vue integration patterns, fixing scope loss, or replacing anti-patterns such as business logic in watch, imperative calls in effects, and direct getState business reads.
Apple HIG guidance for Apple technology integrations: Siri, Apple Pay, HealthKit, HomeKit, ARKit, machine learning, generative AI, iCloud, Sign in with Apple, SharePlay, CarPlay, Game Center, in-app purchase, NFC, Wallet, VoiceOver, Maps, Mac Catalyst, and more. Use when asked about: "Siri integration", "Apple Pay", "HealthKit", "HomeKit", "ARKit", "augmented reality", "machine learning", "generative AI", "iCloud sync", "Sign in with Apple", "SharePlay", "CarPlay", "in-app purchase", "NFC", "VoiceOver", "Maps", "Mac Catalyst". Also use when the user says "how do I integrate Siri," "what are the Apple Pay guidelines," "how should my AR experience work," "how do I use Sign in with Apple," or asks about any Apple framework or service integration. Cross-references: hig-inputs for input methods, hig-components-system for widgets.
Lightning Web Components development skill with PICKLES architecture methodology, component scaffolding, wire service patterns, event handling, Apex integration, GraphQL support, and Jest test generation. Build modern Salesforce UIs with proper reactivity, accessibility, dark mode compatibility, and performance patterns.
Create and use brand.yml files for consistent branding across Shiny apps and Quarto documents. Use when working with brand styling, colors, fonts, logos, or corporate identity in Shiny or Quarto projects. Covers: (1) Creating new _brand.yml files from brand guidelines, (2) Applying brand.yml to Shiny for R apps with bslib, (3) Applying brand.yml to Shiny for Python apps with ui.Theme, (4) Using brand.yml in Quarto documents, presentations, dashboards, and PDFs, (5) Modifying existing brand.yml files, (6) Troubleshooting brand integration issues. Includes complete specifications and framework-specific integration guides.
Best practices for the Common utilities package in LlamaFarm. Covers HuggingFace Hub integration, GGUF model management, and shared utilities.
Guide for implementing 1Password secrets management - CLI operations, service accounts, Developer Environments, and Kubernetes integration. Use when retrieving secrets, managing vaults, configuring CI/CD pipelines, integrating with External Secrets Operator, managing Developer Environments, or automating secrets workflows with 1Password.
Comprehensive guide for managing Cloudflare DNS with Azure integration. Use when configuring Cloudflare as authoritative DNS provider for Azure-hosted applications, managing DNS records via API, setting up API tokens, configuring proxy settings, troubleshooting DNS issues, implementing DNS security best practices, or integrating External-DNS with Cloudflare for Kubernetes workloads.
Use when building 3D content, AR experiences, or spatial computing with RealityKit. Covers ECS architecture, SwiftUI integration, RealityView, AR anchors, materials, physics, interaction, multiplayer, performance.
Expert in mise—a fast, flexible polyglot runtime and task manager. Specializes in tool version management, environment variable control, task automation, and shell integration across development workflows.