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Found 939 Skills
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Write idiomatic Ruby code with metaprogramming, Rails patterns, and performance optimization. Specializes in Ruby on Rails, gem development, and testing frameworks. Use PROACTIVELY for Ruby refactoring, optimization, or complex Ruby features.
RealityKit API reference — Entity, Component, System, RealityView, Model3D, anchor types, material system, physics, collision, animation, audio, accessibility
Senior Laravel Engineer role for production-grade, maintainable, and idiomatic Laravel solutions. Focuses on clean architecture, security, performance, and modern standards (Laravel 10/11+).
Custom training plans by goal (strength, cardio, flexibility). Progressive overload programming, rest day optimization, home vs gym adaptations, deload weeks.
Generate idiomatic Typst (.typ) code, edit existing Typst files, and answer Typst syntax questions. Use when working with Typst files (*.typ) or when the user mentions Typst markup, document creation, or formatting.
Conduct rigorous, adversarial code reviews with zero tolerance for mediocrity. Use when users ask to "critically review" my code or a PR, "critique my code", "find issues in my code", or "what's wrong with this code". Identifies security holes, lazy patterns, edge case failures, and bad practices across Python, R, JavaScript/TypeScript, SQL, and front-end code. Scrutinizes error handling, type safety, performance, accessibility, and code quality. Provides structured feedback with severity tiers (Blocking, Required, Suggestions) and specific, actionable recommendations.
Use when developing Roblox games or experiences and need to earn Robux through Game Passes, Developer Products, UGC avatar items, or Premium Payouts — covers both Studio scripting and Creator Hub dashboard setup.
Text-to-speech conversion using GLM-TTS service via the `uvx zai-tts` command for generating audio from text. Use when (1) User requests audio/voice output with the "tts" trigger or keyword. (2) Content needs to be spoken rather than read (multitasking, accessibility, podcast, driving, cooking). (3) Using pre-cloned voices for speech.
Process videos with the VideoDB Python SDK. Handles trimming, combining clips, audio overlays, background music, subtitles, transcription, voiceover, text/image overlays, transcoding, resolution change, aspect-ratio fix, resizing for social platforms, media generation, search, and real-time capture — all server-side with no ffmpeg or local encoding tools needed.
Process videos with the VideoDB Python SDK. Handles trimming, combining clips, audio overlays, background music, subtitles, transcription, voiceover, text/image overlays, transcoding, resolution change, aspect-ratio fix, resizing for social platforms, media generation, search, and real-time capture — all server-side with no ffmpeg or local encoding tools needed.
Advanced TypeScript patterns for strict mode development. Covers type utilities (Pick, Omit, Partial, Record, Awaited), generics with constraints and inference, type guards and narrowing, discriminated unions, conditional and mapped types, template literal types, const assertions, satisfies operator, module patterns, and modern JavaScript idioms (eslint-plugin-unicorn). Use when building type-safe APIs, preventing runtime errors through types, working with strict TypeScript configuration, debugging complex type errors, or enforcing modern JS idioms. Use for generics, type guards, utility types, strict mode, type inference, narrowing, type safety, const assertions, satisfies, module augmentation, unicorn, for-of, modern-js.