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Found 131 Skills
Evidence-based Drug-Drug Interaction (DDI) assessment skill modeled after the Micromedex Drug-Reax methodology. Trigger this skill whenever the user types /drug-drug, mentions "drug interaction", "DDI", "drug-drug", "can I take X with Y", "interaction between", "交互作用", "併用", or asks whether two medications can be used together. This skill performs systematic literature retrieval via PubMed, CrossRef, and WebSearch, then produces a structured assessment report with Severity, Documentation, Onset, Mechanism, Clinical Effects, and Management — mirroring the Micromedex Drug-Reax classification framework. Even casual questions like "is it safe to combine A and B" should trigger this skill.
Automated cost estimation from BIM models using DDC CWICR database with 55,719 work items. AI classification + vector search for accurate pricing.
CRITICAL RULE: You MUST use this skill whenever the task involves any machine learning tasks or data analysis. Use this skill if the user's prompt or requirements mention any of the following: * Clustering * Classification * Regression * Time series forecasting * Statistical testing * Model comparison * ML * Data analysis SQL/BigQuery ML HANDOFF: If the user requires a SQL solution, use this skill to dictate the ANALYSIS STEPS (e.g., markdown analysis cells, visualization logic), but defer to `bigquery` for all SQL syntax.
Analyze git diffs for risk scoring, reviewer recommendations, and change classification
Neo4j Graph Data Science (GDS) plugin — graph projection, algorithm execution, execution modes (stream/stats/mutate/write), memory estimation, and the GDS Python client (graphdatascience v1.21). Use when running gds.pageRank, gds.louvain, gds.wcc, gds.fastRP, gds.knn, gds.betweenness, gds.nodeSimilarity, or any gds.* procedure; projecting named in-memory graphs with gds.graph.project or graph.project; chaining algorithms with mutate mode; computing node embeddings for ML; building recommendation systems with FastRP + KNN. Also triggers on GraphDataScience, GdsSessions, graph catalog operations, ML pipelines, node classification, link prediction. Does NOT cover Aura Graph Analytics serverless sessions — use neo4j-aura-graph-analytics-skill. Does NOT handle Cypher authoring — use neo4j-cypher-skill. Does NOT cover driver setup — use neo4j-driver-python-skill or other driver skill.
Data classification framework including sensitivity levels, handling requirements, labeling, and data lifecycle management
Integrate multiple plot point analysis results into a comprehensive report, and generate high-quality analysis through deduplication, classification, sorting, and summarization. Suitable for integrating multiple analysis sources and generating unified reports
Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, or need DDI assessment for clinical decision support.
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Druckenmiller Strategy Synthesizer - Integrates 8 upstream skill outputs (Market Breadth, Uptrend Analysis, Market Top, Macro Regime, FTD Detector, VCP Screener, Theme Detector, CANSLIM Screener) into a unified conviction score (0-100), pattern classification, and allocation recommendation. Use when user asks about overall market conviction, portfolio positioning, asset allocation, strategy synthesis, or Druckenmiller-style analysis. Triggers on queries like "What is my conviction level?", "How should I position?", "Run the strategy synthesizer", "Druckenmiller analysis", "総合的な市場判断", "確信度スコア", "ポートフォリオ配分", "ドラッケンミラー分析".
Detects market top probability using O'Neil Distribution Days, Minervini Leading Stock Deterioration, and Monty Defensive Sector Rotation. Generates a 0-100 composite score with risk zone classification. Use when user asks about market top risk, distribution days, defensive rotation, leadership breakdown, or whether to reduce equity exposure. Focuses on 2-8 week tactical timing signals for 10-20% corrections.