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Found 1,086 Skills
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
GitHub CLI operations via `gh` for issues, pull requests, CI/Actions, releases, repos, search, gists, and the REST/GraphQL API. Structured output with `--json` and `--jq` for parsing. Covers `gh issue create/list/view/edit/close`, `gh pr create/review/merge/checks`, `gh run list/view/rerun/watch`, `gh release create`, `gh search repos/issues/prs/code`, `gh api` for REST and GraphQL queries, and `gh gist` operations. Includes error handling for HTTP 401/403/404/422/429, scope troubleshooting, and rate limit management. Trigger phrases: "create an issue", "file a bug", "open a ticket", "submit a PR", "raise a pull request", "check pipeline", "view test results", "CI failing", "why did CI fail", "check CI status", "merge a PR", "manage releases", "query the GitHub API", "search repositories", "triage workflows", "automate GitHub operations". Also triggers when the user pastes a GitHub URL.
Guide for publishing packages to the npm registry. Use this skill when the user wants to publish a new package, release a new version, or manage npm package configurations.
This skill is used when users mention "create issue", "register bug", "create task", "issue list", "my tasks", "assigned issues", "update issue", "change issue status", "search issues", "ticket", "issue", "bug report", etc. Provides Redmine issue management functionality.
Create and manage Circle developer-controlled wallets where the application retains full custody of wallet keys on behalf of end-users. Covers wallet sets, entity secret registration, token transfers, and balance checks via the developer controlled wallets SDK. Triggers on: developer-controlled wallets, dev-controlled wallets, create wallet, wallet set, entity secret, transfer tokens, check balance, EOA wallet, SCA wallet, initiateDeveloperControlledWalletsClient, createWalletSet, createWallets, custody wallet.
Track investment theses across their lifecycle — from screening idea to closed position with postmortem. Register theses from screener outputs, manage state transitions, attach position sizing, review due dates, and generate postmortem reports with P&L and MAE/MFE analysis. Trigger when user says "register thesis", "track this idea", "thesis status", "review due", "close position", "postmortem", or "trading journal".
Wire Credyt billing into your application code. Adds customer creation to registration, usage event tracking, balance checks, cost tracking, and billing portal links. Run after /credyt:billing-setup and /credyt:billing-verification. Use when the user wants to add Credyt to their app, integrate billing, send events from code, show balances, or add a billing page.
Use when optimizing application performance, reducing load times, improving database queries, meeting performance budgets, or diagnosing bottlenecks in web applications or APIs. Triggers: slow page loads, poor Web Vitals, database timeouts, large bundle size, user-reported sluggishness, scaling preparation.
IDAPython and IDALib script reference for reverse engineering. Activate when the user needs to write IDAPython scripts in IDA, use IDALib for headless analysis, operate on IDB databases, debug with IDA, manipulate memory/registers, traverse functions/blocks/instructions, work with Hex-Rays decompiler API, handle obfuscation, or batch-process binaries.
Use this skill when overlaying HTML elements on the PixiJS v8 canvas. Covers DOMContainer with element, anchor, and scene-graph-driven CSS transforms, the pixi.js/dom side-effect import, DOMPipe registration, visibility sync, pointer-events handling. Triggers on: DOMContainer, pixi.js/dom, DOMPipe, HTML overlay, input on canvas, iframe overlay, DOMContainerOptions, element, anchor, constructor options.
Annie Duke's Decision Quality framework applied to a business decision. Spawns a team of specialist agents — Resulting Auditor, Calibrator, Pre-Mortem Analyst, Quit Strategist, Process Architect — who each apply a distinct lens from Duke's framework to evaluate whether a decision is sound regardless of outcome. The lead synthesizes into a stacking analysis: which biases are operating, which process flaws exist, and the honest Duke verdict. Use when the user says "duke this", "is this a good bet", "should I quit", "evaluate this decision", or faces any high-stakes choice under uncertainty and wants rigorous decision-process analysis. Works as a standalone analysis or after /office-hours.
Create a new Architecture Decision Record with sequential numbering and AgentDB registration