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Found 1,248 Skills
Rare disease genomics research -- disease identification via Orphanet, causative gene discovery, gene-disease validity assessment via GenCC, pathogenic variant lookup via ClinVar, HPO phenotype mapping, epidemiology and prevalence data, clinical trial search, and literature review. Use when users ask about rare diseases, orphan diseases, genetic causes of rare conditions, Orphanet codes, HPO phenotypes, gene-disease validity, rare disease prevalence, or treatment options for rare genetic disorders.
Investigate transcription factor binding, cis-regulatory elements, chromatin accessibility, and regulatory variant annotation. Use when asked about TF binding sites, enhancers, promoters, ChIP-seq data, ATAC-seq signals, candidate cis-regulatory elements (cCREs), or the regulatory impact of genomic variants.
Translate free-text tumor descriptions to OncoTree codes, look up cancer subtypes and tissue hierarchies, resolve UMLS/NCI cross-references, and obtain OncoKB-compatible tumor type codes for variant annotation. Use when asked to find the OncoTree code for a tumor type, enumerate subtypes of a cancer, list cancers by tissue of origin, or standardize tumor nomenclature for downstream precision oncology analysis.
Population genetics research using the 1000 Genomes Project (IGSR) -- search populations by superpopulation ancestry (AFR, AMR, EAS, EUR, SAS), retrieve samples by population code, list available data collections, and integrate with GWAS tools for population stratification analysis. Use when users ask about 1000 Genomes populations, sample ancestry, allele frequency variation across continental groups, population-specific GWAS interpretation, or IGSR data collections like the 30x high-coverage resequencing or HGSVC.
Connect GWAS variants to biological pathways for drug target discovery. Maps disease-associated SNPs to causal genes via eQTL colocalization (GTEx), links genes to enriched pathways (Reactome, KEGG, MetaCyc), and identifies druggable targets within disease-relevant pathways. Use when asked to translate GWAS findings into mechanistic insights, find pathways enriched for disease genes, discover drug targets from genetic evidence, or answer questions like "What pathways are disrupted in type 2 diabetes based on GWAS data?"
Guide pharmacogenomics (PGx) research -- drug-gene interaction lookup, CPIC guideline retrieval, variant-drug annotation, allele function status, FDA biomarker labeling, and clinical dosing recommendations. Covers the full CPIC-to-PharmGKB-to-clinical-recommendation workflow. Use when users ask about pharmacogenomics, drug-gene interactions, CPIC guidelines, genotype-guided dosing, PGx biomarkers, CYP enzyme phenotypes, or star allele interpretation.
When the user wants to design, deploy, or measure Apple Custom Product Pages (CPP) — the alternate App Store product pages with different screenshots, preview videos, and promo text shown to users coming from specific URLs (typically ad campaigns or social posts). Use when the user mentions "Custom Product Page", "CPP", "alternate product page", "App Store URL variant", "ASA CPP", "campaign-specific landing page", "product page per audience", "App Store Connect CPP", "ppoUrl", "?cpp=" parameter, or "show different screenshots to different ad audiences". For App Store A/B tests on the default page, see ab-test-store-listing. For paid ad campaigns that route to CPPs, see apple-search-ads or ua-campaign.
Review web application code for bugs, security issues, performance problems, and stack-specific anti-patterns. Use this skill whenever the user wants to review code, debug a production issue, investigate a build failure, audit security, or check a PR before merging. Triggers on code review, review my code, debug, build error, broken, not working, why is X failing, check this code, security check, PR review, audit code, refactor. Also triggers when investigating 4xx or 5xx errors, deploy failures, environment variable issues, and CMS integration problems.
Cross-format content adaptation. Turning one substantial piece into many derivative formats (blog series, email sequences, social posts, webinars, podcasts, video shorts) without losing the original's value or producing AI-slop variants. The discipline of adaptation per medium rather than mass-blast distribution. Triggers on content repurposing, content adaptation, cross-format content, content atomization, content multiplication, content distribution across formats, source-piece-to-derivative, video shorts from blog, email from whitepaper, podcast from article, blog series from research. Also triggers when a flagship piece is shipping but the team has not planned how to extend it across formats, when repurposing is happening but the derivatives feel mass-produced, or when AI-assisted repurposing is producing slop variants of strong source pieces.
Run conversion rate optimization through hypothesis-driven testing including audit, hypothesis generation, test design, statistical analysis, and rollout decisions. Use this skill whenever the user wants to optimize conversion, run A/B tests, audit a funnel, generate test hypotheses, design experiments, or analyze test results. Triggers on conversion optimization, CRO, A/B test, split test, multivariate test, hypothesis, conversion funnel, funnel audit, experiment design, statistical significance, lift, optimization. Also triggers when the user has a conversion problem and isn't sure where to start, or when test results are ambiguous and need interpretation.
Use when naming or renaming TypeScript identifiers, especially cryptic names, ambiguous parameters, I-prefixed interfaces, Hungarian notation, misleading side effects, or requests for clearer names.
Design and engineer System Prompts, prompt templates, and multi-agent orchestration contracts for deterministic, leak-proof AI systems. Use when creating agents, writing skill definitions, designing prompt templates with safe variable injection, structuring I/O contracts, or building multi-agent pipelines.