Loading...
Loading...
Found 6 Skills
Expands one confirmed or suspected vulnerability into a Trailmark graph neighborhood of variant candidates by finding sibling functions, shared callers and callees, common sensitive sinks, common entrypoint paths, interface implementations, override relationships, type/reference neighbors, and structurally similar nodes. Use after one issue is found to seed variant-analysis, semgrep-rule-creator, static-analysis, or manual review with graph-derived candidate locations.
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.
Security vulnerability detection and variant analysis skill. Use when hunting for dangerous APIs, footgun patterns, error-prone configurations, and vulnerability variants across codebases. Combines sharp edges detection with variant hunting methodology.
Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.
Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.
Use when a confirmed local bug needs an invariant-level fix, variant search, tests, and one local commit.