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Found 9 Skills
Provides exact Enzyme → React Testing Library migration patterns for React 18 upgrades. Use this skill whenever Enzyme tests need to be rewritten - shallow, mount, wrapper.find(), wrapper.simulate(), wrapper.prop(), wrapper.state(), wrapper.instance(), Enzyme configure/Adapter calls, or any test file that imports from enzyme. This skill covers the full API mapping and the philosophy shift from implementation testing to behavior testing. Always read this skill before rewriting Enzyme tests - do not translate Enzyme APIs 1:1, that produces brittle RTL tests.
Access BRENDA enzyme database via SOAP API. Retrieve kinetic parameters (Km, kcat), reaction equations, organism data, and substrate-specific enzyme information for biochemical research and metabolic pathway analysis.
Foundation skill for autonomous protein engineering via the Amina CLI. Use at session start or after conversation compacting when working with AminoAnalytica's Amina CLI or when you need help using the Amina CLI to do protein engineering tasks like: protein design, structure prediction, binder design, docking, molecular dynamics, enzyme engineering, or any mention of Amina/amina-cli.
Design novel protein therapeutics (binders, enzymes, scaffolds) using AI-guided de novo design. Uses RFdiffusion for backbone generation, ProteinMPNN for sequence design, ESMFold/AlphaFold2 for validation. Use when asked to design protein binders, therapeutic proteins, or engineer protein function.
Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
Analyze metabolomics data including metabolite identification, quantification, pathway analysis, and metabolic flux. Processes LC-MS, GC-MS, NMR data from targeted and untargeted experiments. Performs normalization, statistical analysis, pathway enrichment, metabolite-enzyme integration, and biomarker discovery. Use when analyzing metabolomics datasets, identifying differential metabolites, studying metabolic pathways, integrating with transcriptomics/proteomics, discovering metabolic biomarkers, performing flux balance analysis, or characterizing metabolic phenotypes in disease, drug response, or physiological conditions.
Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.
Guide pharmacogenomics (PGx) research -- drug-gene interaction lookup, CPIC guideline retrieval, variant-drug annotation, allele function status, FDA biomarker labeling, and clinical dosing recommendations. Covers the full CPIC-to-PharmGKB-to-clinical-recommendation workflow. Use when users ask about pharmacogenomics, drug-gene interactions, CPIC guidelines, genotype-guided dosing, PGx biomarkers, CYP enzyme phenotypes, or star allele interpretation.
Interpret medical lab/test reports (blood panels, urine, liver/kidney function, thyroid, tumor markers, coagulation, cardiac enzymes, hormones, etc.) uploaded as images, PDFs, or text. Trigger whenever the user uploads a lab report, medical test result, or clinical diagnostic sheet — or says things like "help me read this report", "what do these results mean", "化验单", "检验报告", "帮我看看这个报告", "blood test results", "lab results", "体检报告", "检查报告单", "血常规", "尿常规", "肝功能", "肾功能", "甲功", "凝血", "interpret my labs", "are these results normal", "这些指标正常吗". Also trigger when the user uploads ANY medical-looking document with tables of values, reference ranges, or clinical test names — even if they don't explicitly ask for interpretation. Do NOT trigger for symptom triage (use emergency-triage instead), drug interaction queries, or general medical Q&A without an actual report to interpret.