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Found 209 Skills
Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.
Prioritization frameworks — RICE, WSJF, ICE, MoSCoW, and opportunity cost scoring for backlog ranking. Use when prioritizing features, comparing initiatives, justifying roadmap decisions, or evaluating trade-offs between competing work items.
RICE, ICE, WSJF, MoSCoW and other prioritization frameworks for product backlogs. Use when scoring features, ranking initiatives, or deciding what to build next.
Prioritize features and backlog items using RICE scoring and Linear's enablers vs blockers lens. Use when asked to rank features, prioritize a backlog, decide what to build next, or evaluate feature requests against each other.
Analyze, rank, and prioritize trading strategies using multi-factor scoring. Use when creating prioritization plans, ranking strategies, analyzing strategy portfolios, comparing strategy performance, or making strategy selection decisions.
Calculate RICE scores and prioritize features systematically. Use when building your product roadmap and need to make data-driven prioritization decisions.
Guide product managers in choosing the right prioritization framework by asking adaptive questions about product stage, team context, decision-making needs, and stakeholder dynamics. Use this to avoid
Prioritization techniques including MoSCoW, Kano model, weighted scoring, and value-effort matrices. Ranks requirements, features, backlog items, and investment decisions.
Reference guide to 9 prioritization frameworks with formulas, when-to-use guidance, and templates — RICE, ICE, Kano, MoSCoW, Opportunity Score, and more. Use when selecting a prioritization method, comparing frameworks like RICE vs ICE, or learning how different prioritization approaches work.
Master prioritization frameworks, roadmap planning, timeline estimation, and resource allocation. Create executable roadmaps that drive focus and alignment.
A framework for classifying product decisions based on impact and reversibility. Use this when you feel like a bottleneck for your team, when you have a massive backlog of choices to make, or when you need to justify spending weeks of research on a single high-stakes problem.
Comprehensive toolkit for product managers including RICE prioritization, customer interview analysis, PRD templates, discovery frameworks, and go-to-market strategies. Use for feature prioritization, user research synthesis, requirement documentation, and product strategy development.