adaptyv

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Adaptyv

Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein sequences via API or web interface and receive experimental results in approximately 21 days.

Adaptyv是一个提供自动化蛋白质测试与验证服务的云端实验室平台。你可以通过API或网页界面提交蛋白质序列，约21天后即可获取实验结果。

Quick Start

快速开始

Authentication Setup

认证设置

Adaptyv requires API authentication. Set up your credentials:

Contact support@adaptyvbio.com to request API access (platform is in alpha/beta)
Receive your API access token
Set environment variable:

bash

export ADAPTYV_API_KEY="your_api_key_here"

Or create a

.env

file:

ADAPTYV_API_KEY=your_api_key_here

Adaptyv需要API认证。请设置你的凭证：

联系support@adaptyvbio.com申请API访问权限（平台目前处于alpha/beta测试阶段）
接收你的API访问令牌
设置环境变量：

bash

export ADAPTYV_API_KEY="your_api_key_here"

或创建一个

.env

文件：

ADAPTYV_API_KEY=your_api_key_here

Installation

安装

Install the required package using uv:

bash

uv pip install requests python-dotenv

使用uv安装所需包：

bash

uv pip install requests python-dotenv

Basic Usage

基础使用

Submit protein sequences for testing:

python

import os
import requests
from dotenv import load_dotenv

load_dotenv()

api_key = os.getenv("ADAPTYV_API_KEY")
base_url = "https://kq5jp7qj7wdqklhsxmovkzn4l40obksv.lambda-url.eu-central-1.on.aws"

headers = {
    "Authorization": f"Bearer {api_key}",
    "Content-Type": "application/json"
}

提交蛋白质序列进行测试：

python

import os
import requests
from dotenv import load_dotenv

load_dotenv()

api_key = os.getenv("ADAPTYV_API_KEY")
base_url = "https://kq5jp7qj7wdqklhsxmovkzn4l40obksv.lambda-url.eu-central-1.on.aws"

headers = {
    "Authorization": f"Bearer {api_key}",
    "Content-Type": "application/json"
}

Submit experiment

response = requests.post( f"{base_url}/experiments", headers=headers, json={ "sequences": ">protein1\nMKVLWALLGLLGAA...", "experiment_type": "binding", "webhook_url": "https://your-webhook.com/callback" } )

experiment_id = response.json()["experiment_id"]

undefined

experiment_id = response.json()["experiment_id"]

undefined

Available Experiment Types

可用实验类型

Adaptyv supports multiple assay types:

Binding assays - Test protein-target interactions using biolayer interferometry
Expression testing - Measure protein expression levels
Thermostability - Characterize protein thermal stability
Enzyme activity - Assess enzymatic function

See

reference/experiments.md

for detailed information on each experiment type and workflows.

Adaptyv支持多种试验类型：

结合试验 - 使用生物层干涉法测试蛋白质-靶点相互作用
表达测试 - 测量蛋白质表达水平
热稳定性 - 表征蛋白质热稳定性
酶活性 - 评估酶功能

如需了解每种实验类型和工作流的详细信息，请查看

reference/experiments.md

。

Protein Sequence Optimization

蛋白质序列优化

Before submitting sequences, optimize them for better expression and stability:

Common issues to address:

Unpaired cysteines that create unwanted disulfides
Excessive hydrophobic regions causing aggregation
Poor solubility predictions

Recommended tools:

NetSolP / SoluProt - Initial solubility filtering
SolubleMPNN - Sequence redesign for improved solubility
ESM - Sequence likelihood scoring
ipTM - Interface stability assessment
pSAE - Hydrophobic exposure quantification

See

reference/protein_optimization.md

for detailed optimization workflows and tool usage.

提交序列前，可对其进行优化以提升表达量和稳定性：

需要解决的常见问题：

未配对的半胱氨酸会形成不必要的二硫键
过多的疏水区域导致聚集
溶解度预测结果不佳

推荐工具：

NetSolP / SoluProt - 初步溶解度筛选
SolubleMPNN - 重新设计序列以提升溶解度
ESM - 序列可能性评分
ipTM - 界面稳定性评估
pSAE - 疏水性暴露量化

如需了解详细的优化工作流和工具使用方法，请查看

reference/protein_optimization.md

。

API Reference

API参考

For complete API documentation including all endpoints, request/response formats, and authentication details, see

reference/api_reference.md

如需包含所有端点、请求/响应格式和认证详情的完整API文档，请查看

reference/api_reference.md

。

Examples

示例

For concrete code examples covering common use cases (experiment submission, status tracking, result retrieval, batch processing), see

reference/examples.md

如需涵盖常见用例（实验提交、状态跟踪、结果获取、批量处理）的具体代码示例，请查看

reference/examples.md

。

Important Notes

重要说明

Platform is currently in alpha/beta phase with features subject to change
Not all platform features are available via API yet
Results typically delivered in ~21 days
Contact support@adaptyvbio.com for access requests or questions
Suitable for high-throughput AI-driven protein design workflows

平台目前处于alpha/beta测试阶段，功能可能会有所变更
并非所有平台功能都已通过API开放
结果通常在约21天内交付
如有访问请求或问题，请联系support@adaptyvbio.com
适用于高通量AI驱动的蛋白质设计工作流