Total 50,502 skills, AI & Machine Learning has 8477 skills
Showing 12 of 8477 skills
Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.
Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.
ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.
This skill should be used when the user asks to generate content such as titles, slogans, dialogues, or scripts. It provides content generation capabilities for various platforms (WeChat, Xiaohongshu, Zhihu, Douyin) with support for batch generation, history deduplication, and diversity guarantee. Supports podcast script generation with platform-specific adaptation.
Edit opencode.json, AGENTS.md, and config files. Use proactively for provider setup, permission changes, model config, formatter rules, or environment variables. Examples: - user: "Add Anthropic as a provider" → edit opencode.json providers, add API key baseEnv var, verify with opencode run test - user: "Restrict this agent's permissions" → add permission block to agent config, set deny/allow for tools/fileAccess - user: "Set GPT-5 as default model" → edit global or agent-level model preference, verify model name format - user: "Disable gofmt formatter" → edit formatters section, set languages.gofmt.enabled = false
Architecting real-time Voice AI agents.
Understanding Reinforcement Learning from Human Feedback (RLHF) for aligning language models. Use when learning about preference data, reward modeling, policy optimization, or direct alignment algorithms like DPO.
Use when working on vLLM Studio backend architecture (controller runtime, Pi-mono agent loop, OpenAI-compatible endpoints, LiteLLM gateway, inference process, and debugging commands).
Evidence-based health research using tiered trusted sources with GRADE-inspired evidence ratings. Integrates Apple Health data for personalized context. Use when user asks health, nutrition, exercise, sleep, or wellness questions.
Always Auto-invoked skill that creates/updates workspace AGENTS.md to instruct the agent to always search for existing skills before attempting any scientific task.
Complete knowledge of the runpod-flash framework - SDK, CLI, architecture, deployment, and codebase. Use when working with runpod-flash code, writing @remote functions, configuring resources, debugging deployments, or understanding the framework internals. Triggers on "flash", "runpod-flash", "@remote", "serverless", "deploy", "LiveServerless", "LoadBalancer", "GpuGroup".
A guide to creating efficient Skills. Use this skill when users need to create a new skill (or update an existing one) to extend Claude's capabilities through expertise, workflows, or tool integrations.