Total 32,663 skills
Showing 12 of 32663 skills
Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.
Implement identity and access management. Use when designing authentication, authorization, or user management. Covers OAuth2, OIDC, and RBAC.
Write Swift code for iOS/macOS following best practices. Use when developing with SwiftUI, UIKit, or Swift packages. Covers type safety, concurrency, and tooling.
Generate git commit messages and help with git workflows
Design scalable, reliable software systems. Use when planning new systems, major features, or architecture changes. Covers C4 diagrams, trade-off analysis, and system decomposition.
Manage project context effectively. Use when onboarding, context switching, or maintaining project knowledge. Covers context capture and sharing.
Structure similarity search with Foldseek. Use this skill when: (1) Finding similar structures in PDB/AFDB databases, (2) Structural homology search, (3) Database queries by 3D structure, (4) Finding remote homologs not detected by sequence, (5) Clustering structures by similarity. For sequence similarity, use uniprot BLAST. For structure prediction, use chai or boltz.
Break down large tasks into smaller, actionable items. Use when planning sprints, estimating work, or creating implementation plans. Covers task breakdown strategies.
Guidance for cell-free protein synthesis (CFPS) optimization. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).
All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only generation, use rfdiffusion. For sequence-only design, use proteinmpnn. For structure validation, use boltz.
Structure prediction using Boltz-1/Boltz-2, an open biomolecular structure predictor. Use this skill when: (1) Predicting protein complex structures, (2) Validating designed binders, (3) Need open-source alternative to AF2, (4) Predicting protein-ligand complexes, (5) Using local GPU resources. For QC thresholds, use protein-qc. For AlphaFold2 prediction, use alphafold. For Chai prediction, use chai.
Skill-Loader standards and best practices for Skill Loader. Includes implementation guidelines, common patterns, and testing strategies.